Beside Evaluation of Troponin (BEST) Study

The BEST Study aims to determine whether troponin testing using point of care can accurately diagnose acute myocardial infarction (AMI) in the Emergency Department.

Approximately 3% of patients who attend an Emergency Department have chest pain that the clinician who treats them initially suspects may have been caused by an acute coronary syndrome. The majority of these patients are admitted to hospital however, tests will later identify that only a minority of those patients actually have an acute coronary syndrome. In this study we will evaluate several promising biomarkers that may enable clinicians to make accurate diagnoses based on information available in the Emergency Department.

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POCT & T-MACS

The rapid turnaround time of point of care (POC) cardiac troponin (cTn) assays is highly attractive for crowded Emergency Departments (EDs). We evaluated the diagnostic accuracy of the Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid with a POC cTn assay.

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PhD Project

Expediting the confirmation of acute myocardial infarction with point of care troponin and heart fatty acid binding protein testing to facilitate early intervention in emergency department

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H-FABP Variability

Heart-type fatty acid–binding protein (h-FABP) may help to improve the early diagnosis of acute coronary syndromes in patients presenting to the Emergency Department (ED) with chest pain. A novel qualitative point of care h-FABP lateral flow immunoassay (True Rapid, FABPulous BV) could provide results to clinicians within just 5 minutes. Given the qualitative nature of this test and prior to evaluation in a large diagnostic study, we aimed to determine inter-observer reliability when interpreted contemporaneously by staff in the ED.

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