{"id":850,"date":"2021-02-20T13:09:22","date_gmt":"2021-02-20T13:09:22","guid":{"rendered":"http:\/\/clinicalbiochemistry.net\/?page_id=850"},"modified":"2021-02-20T13:41:10","modified_gmt":"2021-02-20T13:41:10","slug":"confounding-patient-and-treatment-parameters-on-morphokinetics","status":"publish","type":"page","link":"http:\/\/clinicalbiochemistry.net\/?page_id=850","title":{"rendered":"Confounding patient and treatment parameters on morphokinetics"},"content":{"rendered":"\n

An investigation into the effect of potential confounding patient and treatment parameters on an embryo\u2019s morphokinetic profile<\/strong><\/p>\n\n\n\n

Objective:<\/strong> To determine the effect of patient and treatment parameters on nineteen embryo morphokinetic parameters using pronuclear fading as time-zero. <\/p>\n\n\n\n

Patients:<\/strong> Patients undergoing treatment between September 2014 and January 2016 (n=639) whose embryos were cultured in the EmbryoScope\u00ae for six days (n=2376). <\/p>\n\n\n\n

Main Outcome Measure(s):<\/strong> Multiple regression analysis of body mass index, maternal age, infertility diagnosis, treatment type, suppression protocol on time to each cellular division (tn); t2, t3, t4, t5, t6, t7, t8, t9, time to start of compaction (tM), start of blastulation (tSB), full blastocyst (tB) and interval measurements; s2, s3, cc2, cc3, cc4, t9-tM, tM-tSB and tSB-tB. Multiple regression results were considered significant at p<0.05 and beta coefficients were analysed to quantify any significant effects.<\/p>\n\n\n\n

Results:<\/strong> Embryos appeared to be subtly affected by patient and treatment parameters, exhibiting complex relationships between various morphokinetic parameters and specific patient and treatment factors, rather than a systemic effect.<\/p>\n\n\n\n

Conclusion:<\/strong> These findings outline the need for the consideration of confounding factors when assessing an embryo\u2019s ability to achieve implantation. Although morphokinetic parameters have been related to embryo viability, it is likely that this will vary dependent on the embryo\u2019s origin.<\/p>\n\n\n\n

<\/p>\n\n\n\n

<\/div><\/div>\n\n\n\nLink to publisher<\/span><\/a>\n","protected":false},"excerpt":{"rendered":"

An investigation into the effect of potential confounding patient and treatment parameters on an embryo\u2019s morphokinetic profile Objective: To determine the effect of patient and treatment parameters on nineteen embryo morphokinetic parameters using pronuclear fading as time-zero.  Patients: Patients undergoing<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"_links_to":"","_links_to_target":""},"jetpack_shortlink":"https:\/\/wp.me\/P9tPlw-dI","jetpack-related-posts":[{"id":121,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=121","url_meta":{"origin":850,"position":0},"title":"Research Papers","date":"December 22, 2017","format":false,"excerpt":"Body, R., McDowell, G., Carley, S., Ferguson, J. & Mackway-Jones, K. (2010) \u2018Diagnosing acute myocardial infarction with troponins: how low can you go?\u2019 Emerg Med J. 27 pp. 292-296. Body, R., Carley, S., Wibberley, C., McDowell, G., Ferguson, J. & Mackway- Jones, K. (2010) \u2018The value of symptoms and signs\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":255,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=255","url_meta":{"origin":850,"position":1},"title":"Efficacy of Embryo Selection Algorithms","date":"December 31, 2017","format":false,"excerpt":"Barrie, A., Homberg, R., McDowell, G., Brown, J., Kingsland, C. & Troup, S. (2017) Examining the efficacy of six published time-lapsed imaging embryo selection algorithms to predict implantation to demonstrate the need for development of specific, in-house morphokinetic selection algorithms. 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In the appropriate clinical context, the detection of a\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":261,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=261","url_meta":{"origin":850,"position":4},"title":"Time lapse embryo culture","date":"December 31, 2017","format":false,"excerpt":"Barrie, A., Homberg, R., McDowell, G., Brown, J., Kingsland, C., Troup, S. (2017) Embryos cultured in a time lapse system result in superior treatment outcomes: A strict matched pair analysis. Human Fertility 20 pp. 179-185. A retrospective, strict matched-pair analysis on 728 treatment cycles between January 2011 and September 2014\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":646,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=646","url_meta":{"origin":850,"position":5},"title":"Undetectable hs-cTnT","date":"February 7, 2019","format":false,"excerpt":"Body, R., Carley, S.,\u00a0McDowell, G., Jaffe, A.S., France, M., Cruickshank, K., Wibberley, C., Nuttall, M. & Mackway-Jones, K. (2011) \u2018Rapid exclusion of acute myocardial infarction in patients\u2019 with undetectable troponin using a high sensitivity assay.\u2019\u00a0J Am Coll Cardiol58 pp. 1332-1339. Objectives:This paper sought to evaluate whether high sensitivity troponin (hs-cTnT)\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2019\/01\/JACC-paper-e1549807840111.png?fit=400%2C268&resize=350%2C200","width":350,"height":200},"classes":[]}],"_links":{"self":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages\/850"}],"collection":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=850"}],"version-history":[{"count":5,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages\/850\/revisions"}],"predecessor-version":[{"id":865,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages\/850\/revisions\/865"}],"wp:attachment":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=850"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}