{"id":506,"date":"2019-01-01T13:19:01","date_gmt":"2019-01-01T13:19:01","guid":{"rendered":"http:\/\/clinicalbiochemistry.net\/?page_id=506"},"modified":"2019-01-19T09:16:37","modified_gmt":"2019-01-19T09:16:37","slug":"beside-evaluation-of-troponin-best-study","status":"publish","type":"page","link":"http:\/\/clinicalbiochemistry.net\/?page_id=506","title":{"rendered":"Beside Evaluation of Troponin (BEST) Study"},"content":{"rendered":"\n<p>The BEST Study aims to determine whether troponin testing using &nbsp;point of care can accurately diagnose acute myocardial infarction (AMI) in the Emergency Department.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img data-attachment-id=\"154\" data-permalink=\"http:\/\/clinicalbiochemistry.net\/?attachment_id=154\" data-orig-file=\"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/Cardiac-Marker-Test-Pages-1.png?fit=800%2C533\" data-orig-size=\"800,533\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Cardiac Marker Test &#8211; Pages\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/Cardiac-Marker-Test-Pages-1.png?fit=300%2C200\" data-large-file=\"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/Cardiac-Marker-Test-Pages-1.png?fit=750%2C500\" loading=\"lazy\" width=\"750\" height=\"500\" src=\"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/Cardiac-Marker-Test-Pages-1.png?resize=750%2C500\" alt=\"\" class=\"wp-image-154\" srcset=\"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/Cardiac-Marker-Test-Pages-1.png?w=800 800w, https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/Cardiac-Marker-Test-Pages-1.png?resize=300%2C200 300w, https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/Cardiac-Marker-Test-Pages-1.png?resize=768%2C512 768w\" sizes=\"(max-width: 750px) 100vw, 750px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p>Approximately 3% of patients who attend an Emergency Department have chest pain that the clinician who treats them initially suspects may have been caused by an acute coronary syndrome.&nbsp; The majority of these patients are admitted to hospital &nbsp;however, tests will later identify that only a minority of those patients actually have an acute coronary syndrome.&nbsp; In this study we will evaluate several promising biomarkers&nbsp;&nbsp;that may enable clinicians to make accurate diagnoses based on information available in the Emergency Department.<\/p>\n\n\n\n<h2>BEST Study Publications<\/h2>\n\n\n\n\t<div class=\"wppap-main-wrapper wpapap-clearfix\">\n\t\t<ul id=\"thumbs-1\" class=\"wppap-thumbs\" data-conf=\"{&quot;grid&quot;:3}\">\n\t\t\t\t<li class=\"thum-list\">\n\t\t\t\t\t<a data-mfp-src=\"#thumb1\" href=\"#\" class=\"wppap-thumbnail\" style=\"background-image: url('http:\/\/clinicalbiochemistry.net\/wp-content\/uploads\/2019\/01\/T-MACS-and-POCT-e1549808066171.png')\">\n\t\t\t\t\t\t<span class=\"wppap-description\">POCT &#038; T-MACS<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\n\t\t\t\t<li class=\"thum-list\">\n\t\t\t\t\t<a data-mfp-src=\"#thumb2\" href=\"#\" class=\"wppap-thumbnail\" style=\"background-image: url('http:\/\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/Book-Featured.png')\">\n\t\t\t\t\t\t<span class=\"wppap-description\">PhD Project<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\n\t\t\t\t<li class=\"thum-list\">\n\t\t\t\t\t<a data-mfp-src=\"#thumb3\" href=\"#\" class=\"wppap-thumbnail\" style=\"background-image: url('http:\/\/clinicalbiochemistry.net\/wp-content\/uploads\/2019\/01\/HFABP-POCT-Inter-rater-e1549808289885.png')\">\n\t\t\t\t\t\t<span class=\"wppap-description\">H-FABP Variability<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t\t<\/ul>\n\n\t\t<div class=\"wppap-portfolio-content\">\n\n\t\t\t\n\t\t\t\t<div id=\"thumb1\">\n\n\t\t\t\t\t\t\t\t\t\t<div class=\"wppap-medium-12 wppap-columns wppap-right-column\">\n\t\t\t\t\t\t<div class=\"wppap-right-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"wppap-title\">POCT &#038; T-MACS<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"wppap-content\"><p>The rapid turnaround time of point of care (POC) cardiac troponin (cTn) assays is highly attractive for crowded Emergency Departments (EDs). We evaluated the diagnostic accuracy of the Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid with a POC cTn assay.<\/p>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"http:\/\/clinicalbiochemistry.net\/?page_id=568\" class=\"wppap-project-url-btn\" target=\"_blank\">View Project<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t \n\t\t\t\t<div id=\"thumb2\">\n\n\t\t\t\t\t\t\t\t\t\t<div class=\"wppap-medium-12 wppap-columns wppap-right-column\">\n\t\t\t\t\t\t<div class=\"wppap-right-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"wppap-title\">PhD Project<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"wppap-content\"><p><strong>Expediting the confirmation of acute myocardial infarction with point of care troponin and heart fatty acid binding protein testing to facilitate early intervention in emergency department<\/strong><\/p>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"http:\/\/clinicalbiochemistry.net\/?page_id=549\" class=\"wppap-project-url-btn\" target=\"_blank\">View Project<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t \n\t\t\t\t<div id=\"thumb3\">\n\n\t\t\t\t\t\t\t\t\t\t<div class=\"wppap-medium-12 wppap-columns wppap-right-column\">\n\t\t\t\t\t\t<div class=\"wppap-right-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"wppap-title\">H-FABP Variability<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"wppap-content\"><p>Heart-type fatty acid\u2013binding protein (h-FABP) may help to improve the early diagnosis of acute coronary syndromes in patients presenting to the Emergency Department (ED) with chest pain. A novel qualitative point of care h-FABP lateral flow immunoassay (True Rapid, FABPulous BV) could provide results to clinicians within just 5 minutes. Given the qualitative nature of this test and prior to evaluation in a large diagnostic study, we aimed to determine inter-observer reliability when interpreted contemporaneously by staff in the ED.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"http:\/\/clinicalbiochemistry.net\/?page_id=259\" class=\"wppap-project-url-btn\" target=\"_blank\">View Project<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t \t\t<\/div>\n\t<\/div>\n\t\n","protected":false},"excerpt":{"rendered":"<p>The BEST Study aims to determine whether troponin testing using &nbsp;point of care can accurately diagnose acute myocardial infarction (AMI) in the Emergency Department. Approximately 3% of patients who attend an Emergency Department have chest pain that the clinician who<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"_links_to":"","_links_to_target":""},"jetpack_shortlink":"https:\/\/wp.me\/P9tPlw-8a","jetpack-related-posts":[{"id":531,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=531","url_meta":{"origin":506,"position":0},"title":"Manchester Acute Coronary Syndrome Rule (MACS &#038; T-MACS)","date":"January 19, 2019","format":false,"excerpt":"Clinical EvaluationClinical DataBiomarker Development and Validation Current diagnostic methods for acute coronary syndromes lack sensitivity and specificity at the time of presentation to the Emergency Department. The MACS and T-MACS rule has been developed using information available at the time of first presentation and the results from a single blood\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/Research-Papers-Pages-1.png?resize=350%2C200","width":350,"height":200},"classes":[]},{"id":539,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=539","url_meta":{"origin":506,"position":1},"title":"Early Vascular Markers of Acute Coronary Syndromes.","date":"January 11, 2019","format":false,"excerpt":"Purpose: To study the utility of incorporating early vascular activation markers into a clinical decision rule to risk stratify patients according to their risk of a significant myocardial event. Methods:\u00a0We recruited a cohort of patients with symptoms suggest of\u00a0\u00a0ACS presenting to the emergency department. Blood was obtained to determine if\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/Cardiac-Marker-Test-Pages.png?resize=350%2C200","width":350,"height":200},"classes":[]},{"id":568,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=568","url_meta":{"origin":506,"position":2},"title":"T-MACS and POCT Troponin","date":"January 17, 2019","format":false,"excerpt":"The Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid for rapid rule-in and rule-out of acute coronary syndromes using a contemporary point of care troponin assay Richard Body; Malak Almashali; Niall Morris; Phil Moss; Heather Jarman; Andrew Appelboam; Richard Parris; Louisa Chan; Alison Walker; Mark Harrison; Andrea Wootten; Garry McDowellc\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":549,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=549","url_meta":{"origin":506,"position":3},"title":"PhD Project: BEST Study","date":"January 11, 2019","format":false,"excerpt":"Expediting the confirmation of acute myocardial infarction with point of care troponin and heart fatty acid binding protein testing to facilitate early intervention in emergency department Cardiac troponin is the reference standard biomarker for the diagnosis of acute myocardial infarction (AMI). In the appropriate clinical context, the detection of a\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":629,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=629","url_meta":{"origin":506,"position":4},"title":"Risk Factors and AMI","date":"February 7, 2019","format":false,"excerpt":"Body, R.,\u00a0McDowell, G.,Carley, S. & Mackway-Jones, K. (2008) \u2018Do risk factors for chronic coronary heart disease help diagnose acute myocardial infarction in the emergency department.\u2019\u00a0Resuscitation79 pp. 41-45.\u00a0 Background:Hypertension, hyperlipidaemia, diabetes mellitus, tobacco smoking and a family history of premature coronary artery disease are known to be risk factors for the\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2019\/01\/Risk-factors-for-ED-diagnosis-e1549807935709.png?fit=400%2C313&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":650,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=650","url_meta":{"origin":506,"position":5},"title":"Modified TIMI Score","date":"February 7, 2019","format":false,"excerpt":"Body, R., Carley, S.,\u00a0McDowell, G.\u00a0& Mackway-Jones. K. (2009) \u2018Can a modified TIMI risk score help to guide patient disposition.\u2019\u00a0Emerg Med J26 pp. 95-99.\u00a0 Background: The thrombolysis in myocardial infarction (TIMI) risk score has been shown to risk stratify patients with suspected acute coronary syndromes (ACS) effectively in the emergency department\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2019\/01\/Modified-TIMI-1-e1549807787719.png?fit=400%2C315&resize=350%2C200","width":350,"height":200},"classes":[]}],"_links":{"self":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages\/506"}],"collection":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=506"}],"version-history":[{"count":3,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages\/506\/revisions"}],"predecessor-version":[{"id":511,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages\/506\/revisions\/511"}],"wp:attachment":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}