{"id":457,"date":"2018-12-31T14:50:16","date_gmt":"2018-12-31T14:50:16","guid":{"rendered":"http:\/\/clinicalbiochemistry.net\/?page_id=457"},"modified":"2019-01-19T09:23:45","modified_gmt":"2019-01-19T09:23:45","slug":"abnormal-embryonic-developmental-phenotype","status":"publish","type":"page","link":"http:\/\/clinicalbiochemistry.net\/?page_id=457","title":{"rendered":"Abnormal Embryonic Developmental Phenotype"},"content":{"rendered":"\n<p>Barrie, A., Homberg, R., <strong>McDowell, G<\/strong>., Brown, J., Kingsland, C. &amp; Troup, S. (2017) <strong>Preliminary investigation of the prevalence and implantation potential of abnormal embryonic phenotype assessed using time-lapse imaging.<\/strong> Reprod Biomed Online 34 pp. 455-462.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img data-attachment-id=\"170\" data-permalink=\"http:\/\/clinicalbiochemistry.net\/?attachment_id=170\" data-orig-file=\"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/IVF-Featured.png?fit=200%2C141\" data-orig-size=\"200,141\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"IVF Featured\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/IVF-Featured.png?fit=200%2C141\" data-large-file=\"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/IVF-Featured.png?fit=200%2C141\" loading=\"lazy\" width=\"200\" height=\"141\" src=\"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/IVF-Featured.png?resize=200%2C141\" alt=\"\" class=\"wp-image-170\" data-recalc-dims=\"1\"\/><\/figure>\n\n\n\n<p>This retrospective, single site observational study aimed to delineate five abnormal embryonic developmental phenotypes, assessing their prevalence, development potential and suitability for inclusion in embryo selection models for IVF. In total, 15,819 embryos from 4559 treatment cycles cultured in EmbryoScope\u00ae incubators between January 2014 and January 2016 were included.<\/p>\n\n\n\n<p> Time-lapse images were assessed retrospectively for five abnormal embryo phenotypes: direct cleavage, reverse cleavage, absent cleavage, chaotic cleavage and cell lysis. The prevalence of each abnormal phenotype was assessed. Final embryo disposition, embryo quality and implantation rate were determined and compared with a control embryo cohort. <\/p>\n\n\n\n<p>The collective prevalence for the five abnormal phenotypes was 11.4%; chaotic cleavage and direct cleavage together constituted 9.7%. Implantation rates were 17.4%, 0%, 25%, 2.1% and 0% for direct, reverse, absent, chaotic cleavage and cell lysis, respectively. The overall implantation rate for all abnormal embryos with known implantation status was significantly lower compared with the control population (6.9% versus 38.7%, P &lt; 0.0001). The proportion of good quality embryos in each category of abnormal cleavage remained below 25%. <\/p>\n\n\n\n<p>Embryos exhibiting an abnormal phenotype may have reduced developmental capability, manifested in both embryo quality and implantation potential, when compared with embryos of normal phenotype.<\/p>\n\n\n<a class=\"maxbutton-4 maxbutton maxbutton-rbm-online-paper\" title=\"Link to Full Text of Paper\" href=\"https:\/\/www.rbmojournal.com\/article\/S1472-6483(17)30091-3\/fulltext\"><span class='mb-text'>Full Text<\/span><\/a>","protected":false},"excerpt":{"rendered":"<p>Barrie, A., Homberg, R., McDowell, G., Brown, J., Kingsland, C. &amp; Troup, S. (2017) Preliminary investigation of the prevalence and implantation potential of abnormal embryonic phenotype assessed using time-lapse imaging. Reprod Biomed Online 34 pp. 455-462. This retrospective, single site<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"_links_to":"","_links_to_target":""},"jetpack_shortlink":"https:\/\/wp.me\/P9tPlw-7n","jetpack-related-posts":[{"id":121,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=121","url_meta":{"origin":457,"position":0},"title":"Research Papers","date":"December 22, 2017","format":false,"excerpt":"Body, R., McDowell, G., Carley, S., Ferguson, J. & Mackway-Jones, K. (2010) \u2018Diagnosing acute myocardial infarction with troponins: how low can you go?\u2019 Emerg Med J. 27 pp. 292-296. Body, R., Carley, S., Wibberley, C., McDowell, G., Ferguson, J. & Mackway- Jones, K. (2010) \u2018The value of symptoms and signs\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":191,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=191","url_meta":{"origin":457,"position":1},"title":"Book Chapter: Abnormal Pituitary Function","date":"December 24, 2017","format":false,"excerpt":"McDowell, G. (2016) \u2018Abnormal Pituitary Function\u2019. In: Admed, N. (ed) (2016) Fundamentals of Biomedical Science Clinical Biochemistry. 2nd Edition Oxford University Press. pp 263-283. (21 pages) \u00a0 Learning objectives After studying this chapter you should be able to: Describe the basic structure and function of the endocrine system Explain the\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/Clinical-Biochemistry-Book-pages-227x300.png?resize=350%2C200","width":350,"height":200},"classes":[]},{"id":193,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=193","url_meta":{"origin":457,"position":2},"title":"Book Chapter: Thyroid Function","date":"December 24, 2017","format":false,"excerpt":"McDowell, G. (2016) \u2018Thyroid Disease\u2019. In: Admed, N. (ed) (2016) Fundamentals of Biomedical Science Clinical Biochemistry. 2nd Edition. Oxford University Press. pp 284-299. (16 pages) \u00a0 Learning objectives After studying this chapter you should be able to: Describe the structure and function of the thyroid gland Explain the function of\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2017\/12\/Clinical-Biochemistry-Book-pages-1-227x300.png?resize=350%2C200","width":350,"height":200},"classes":[]},{"id":261,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=261","url_meta":{"origin":457,"position":3},"title":"Time lapse embryo culture","date":"December 31, 2017","format":false,"excerpt":"Barrie, A., Homberg, R., McDowell, G., Brown, J., Kingsland, C., Troup, S. (2017) Embryos cultured in a time lapse system result in superior treatment outcomes: A strict matched pair analysis. Human Fertility 20 pp. 179-185. A retrospective, strict matched-pair analysis on 728 treatment cycles between January 2011 and September 2014\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":641,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=641","url_meta":{"origin":457,"position":4},"title":"A FABP-ulous rule out strategy","date":"February 7, 2019","format":false,"excerpt":"Body, R.,\u00a0McDowell, G., Carley, S., Wibberley, C., Ferguson, J. & Mackway-Jones, K. (2011) \u2018A FABP-ulous rule out strategy? Heart fatty acid binding protein and troponin for rapid exclusion of acute myocardial infarction.\u2019\u00a0Resuscitation82 pp. 1041-1046.\u00a0 Objective:Many Emergency Departments (EDs) utilise \u2018triple marker\u2019 testing with CK-MB, myoglobin and troponin I (cTnI) to\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2019\/01\/Quanti-HFABP-e1549807872944.png?fit=400%2C341&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":850,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=850","url_meta":{"origin":457,"position":5},"title":"Confounding patient and treatment parameters on morphokinetics","date":"February 20, 2021","format":false,"excerpt":"An investigation into the effect of potential confounding patient and treatment parameters on an embryo\u2019s morphokinetic profile Objective: To determine the effect of patient and treatment parameters on nineteen embryo morphokinetic parameters using pronuclear fading as time-zero.\u00a0 Patients: Patients undergoing treatment between September 2014 and January 2016 (n=639) whose embryos\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"_links":{"self":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages\/457"}],"collection":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=457"}],"version-history":[{"count":4,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages\/457\/revisions"}],"predecessor-version":[{"id":582,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages\/457\/revisions\/582"}],"wp:attachment":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=457"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}