{"id":121,"date":"2017-12-22T16:55:26","date_gmt":"2017-12-22T16:55:26","guid":{"rendered":"http:\/\/clinicalbiochemistry.net\/?page_id=121"},"modified":"2021-03-28T09:08:38","modified_gmt":"2021-03-28T09:08:38","slug":"research-papers","status":"publish","type":"page","link":"http:\/\/clinicalbiochemistry.net\/?page_id=121","title":{"rendered":"Research Papers"},"content":{"rendered":"

\"\"Body, R., McDowell, G.<\/strong>, Carley, S., Ferguson, J. & Mackway-Jones, K. (2010) \u2018Diagnosing acute myocardial infarction with troponins: how low can you go?\u2019 Emerg Med J<\/em>. 27 pp. 292-296.<\/p>\n

Body, R., Carley, S., Wibberley, C., McDowell, G.<\/strong>, Ferguson, J. & Mackway- Jones, K. (2010) \u2018The value of symptoms and signs in the emergent diagnosis of acute coronary syndromes.\u2019 Resuscitation<\/em> 81 pp. 281-286.<\/p>\n

Body, R., Pemberton, P., Ali, F., McDowell, G.<\/strong>, Carley, S., Smith, A. & Mackway-Jones, K. (2011) \u2018Low soluble P-selectin may facilitate early exclusion of acute myocardial infarction.\u2019 Clin Chem Acta<\/em> 412 pp. 614-618.<\/p>\n

McDowell, G.<\/strong>, Slevin, M. & Krupinski, J. (2011) \u2018Nanotechnology for treatment of coronary instent restenosis.\u2019 Vascular Cell<\/em> 3: 8.<\/p>\n

Body, R., McDowell, G.<\/strong>, Carley, S., Wibberley, C., Ferguson, J. & Mackway-Jones, K. (2011) \u2018A FABP-ulous rule out strategy? Heart fatty acid binding protein and troponin for rapid exclusion of acute myocardial infarction.\u2019 Resuscitation<\/em> 82 pp. 1041-1046.<\/p>\n

Kirwan, C.C., McDowell, G.<\/strong>, McCollum, C.N. & Byrne, G.J. (2011) \u2018Incidence of venous thromboembolism during chemotherapy for breast cancer: Impact on cancer outcome.\u2019 Anticancer Res 31 pp. 2383-2388.<\/p>\n

Body, R., Carley, S., McDowell, G.<\/strong>, Jaffe, A.S., France, M., Cruickshank, K., Wibberley, C., Nuttall, M. & Mackway-Jones, K. (2011) \u2018Rapid exclusion of acute myocardial infarction in patients\u2019 with undetectable troponin using a high sensitivity assay.\u2019 J Am Coll Cardiol<\/em> 58 pp. 1332-1339.<\/p>\n

Slevin, M., Ahmed, N., Wang, Q., McDowell, G. <\/strong>& Badimon, L. (2012) \u2018Unique vascular protective properties of natural products: supplements of future main-line drugs with significant anti-atherosclerotic potential.\u2019 Vascular Cell<\/em> 4: 9.<\/p>\n

Slevin, M., Baldellou, M., Hill, E., Alexander, Y., McDowell, G<\/strong>., Murgatroyd, C., Carroll, M., Degens, H., Krupinski, J., Rovira, N., Chowdhury, M., Serracino-Inglott, F., Badimon, L. (2014). \u2018Novel methods for accurate identification, isolation, and genomic analysis of symptomatic microenvironments in atherosclerotic arteries.\u2019 Methods Mol Biol<\/em> 1135 pp. 289-305.<\/p>\n

Body, R., Carley, S., McDowell, G<\/strong>., Pemberton, P., Burrows, G., Cook, G., Lewis, P.S., Smith, A., Mackway-Jones, K. (2014) \u2018The Manchester Acute Coronary Syndromes (MACS) decision rule for suspected cardiac chest pain: derivation and external validation.\u2019 Heart 100 pp. 1462-1468.<\/p>\n

Kirwan, C.C., McCollum, C.N., McDowell, G<\/strong>. & Byrne, G.J. (2015) \u2018Investigation of proposed mechanisms of chemotherapy-induced venous thromboembolism: Endothelial cell activation and pro-coagulant release due to apoptosis. Clinical and Applied Thrombosis and Haemostasis 21 pp. 420-427.<\/p>\n

Body, R., Carlton, E., Sperrin, M., Lewis, P.S., Burrows, G., Carley, S., McDowell, G<\/strong>., Buchan, I., Greaves, K. & Mackway-Jones, K. (2017). Troponin only Manchester Acute Coronary Syndromes (T-MACS) decision aid: single biomarker re-derivation and external validation in three cohorts. Emerg Med J 34 pp. 349-356<\/p>\n

Mashali, M., Norris, N., McDowell, G<\/strong>. & Body, R. (2016) The inter-observer reliability of a novel qualitative point of care assay for heart-type fatty acid binding protein. Clin Biochem 49 pp. 1199-1201<\/p>\n

Barrie, A., Homberg, R., McDowell, G<\/strong>., Brown, J., Kingsland, C., Troup, S. (2017) Embryos cultured in a time lapse system result in superior treatment outcomes: A strict matched pair analysis. Human Fertility 20 pp. 179-185.<\/p>\n

Fang, W-H., Kumar, S., McDowell, G<\/strong>., Smith, D., Krupinski, J., Olah, P., Al-Baradie, R., Al-Rukban, M.O., Petcu, E.B. & Slevin M. (2016) Mesenchymal stem cells loaded with p5, derived from CDK5 Activator p35, inhibit calcium-induced CDK5 activation in endothelial cells. Stem Cells International doi.org\/10.1155\/2016\/2165462.<\/p>\n

Body, R. & McDowell, G<\/strong>. (2017) The rise and fall of cardiac troponin T. Clinical Chemistry 63 pp. 437<\/p>\n

Barrie, A., Homberg, R., McDowell, G<\/strong>., Brown, J., Kingsland, C. & Troup, S. (2017) Examining the efficacy of six published time-lapsed imaging embryo selection algorithms to predict implantation to demonstrate the need for development of specific, in-house morphokinetic selection algorithms. Fert Steril 107 pp. 613-621<\/p>\n

Barrie, A., Homberg, R., McDowell, G<\/strong>., Brown, J., Kingsland, C. & Troup, S. (2017) Preliminary investigation of the prevalence and implantation potential of abnormal embryonic phenotype assessed using time-lapse imaging. Reprod Biomed Online 34 pp. 455-462.<\/p>\n

Slevin, M., Lemma, R.S., Zeinolabediny, Y., Liu, D., Ferris, G.R., Caprio, V., Phillips, N., Di Napoli, M., Guo, B., Zeng, X., AlBaradie, R., Binsaleh, N.K., McDowell, G<\/strong>. & Fang, W-H. (2018) Acetylcholine inhibits monomeric C-Reactive Protein inducd inflammation, endothelial cell adhesion and platelet aggregation; A potential therapeutic. Frontiers in Immunology 9 article 2124<\/p>\n

Body, R., Almashali, M., Morris, N., Moss, P., Jarmin. H., Appelboam, A., Parris, R., Chan, L., Walker, A., Harrison, M., Wooten, A. & McDowell, G<\/strong>. (2019) Diagnostic accuracy of the T-MACS decision aid with a contemporary point of care troponin assay. Heart doi: 10.1136\/heartjnl-2018-313825.[epub ahead of print]<\/p>\n

Body, R., Twerenbold, R., Austin, C., Boeffinghaus, J., Almashali, M., Nestleberger, T., Norris, N., Badertscher, P., McDowell, G<\/strong>., Wild, K., Moss, P., Rubini Gimenez, M., Jarmen, H., Bigler, N., Einemann, R., Pourmahram, G., Todd, J., Mueller, C., Freemont, A. (2019) Diagnostic accuracy of a high sensitivity cardiac troponin assay with a single serum test in the emergency department. Clinical Chemistry 65 pp. 1006-1014.<\/p>\n

Barrie, A., McDowell, G<\/strong>., Troup, S. (2021) An investigation into the effect of potential confounding patient and treatment parameters on human embryo morphokinetics. Fertil Steril doi: 10.1016\/j.fertnstert.2020.10.03. [epub ahead of print].<\/p>\n","protected":false},"excerpt":{"rendered":"

Body, R., McDowell, G., Carley, S., Ferguson, J. & Mackway-Jones, K. (2010) \u2018Diagnosing acute myocardial infarction with troponins: how low can you go?\u2019 Emerg Med J. 27 pp. 292-296. Body, R., Carley, S., Wibberley, C., McDowell, G., Ferguson, J. &<\/p>\n","protected":false},"author":1,"featured_media":123,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"_links_to":"","_links_to_target":""},"jetpack_shortlink":"https:\/\/wp.me\/P9tPlw-1X","jetpack-related-posts":[{"id":629,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=629","url_meta":{"origin":121,"position":0},"title":"Risk Factors and AMI","date":"February 7, 2019","format":false,"excerpt":"Body, R.,\u00a0McDowell, G.,Carley, S. & Mackway-Jones, K. (2008) \u2018Do risk factors for chronic coronary heart disease help diagnose acute myocardial infarction in the emergency department.\u2019\u00a0Resuscitation79 pp. 41-45.\u00a0 Background:Hypertension, hyperlipidaemia, diabetes mellitus, tobacco smoking and a family history of premature coronary artery disease are known to be risk factors for the\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2019\/01\/Risk-factors-for-ED-diagnosis-e1549807935709.png?fit=400%2C313&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":637,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=637","url_meta":{"origin":121,"position":1},"title":"Symptoms and Signs in ACS","date":"February 7, 2019","format":false,"excerpt":"Body, R., Carley, S., Wibberley, C.,\u00a0McDowell, G., Ferguson, J. & Mackway- Jones, K. (2010) \u2018The value of symptoms and signs in the emergent diagnosis of acute coronary syndromes.\u2019\u00a0Resuscitation81 pp. 281-286.\u00a0 Objective:Patient history and physical examination are widely accepted as cornerstones of diagnosis in modern medicine. We aimed to assess the\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2019\/01\/Symptoms-and-Signs-e1549807905811.png?fit=400%2C311&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":654,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=654","url_meta":{"origin":121,"position":2},"title":"Does Troponin Cut-off Matter?","date":"February 7, 2019","format":false,"excerpt":"Body, R.,\u00a0McDowell, G., Carley, S., Ferguson, J. & Mackway-Jones, K. (2010) \u2018Diagnosing acute myocardial infarction with troponins: how low can you go?\u2019\u00a0Emerg Med J. 27 pp. 292-296. Background:Recent consensus guidelines state that acute myocardial infarction (AMI) may be diagnosed in the context of a troponin rise above the 99th percentile\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2019\/01\/Tn-How-low-can-you-go-e1549807753211.png?fit=400%2C325&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":659,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=659","url_meta":{"origin":121,"position":3},"title":"MACS Rule","date":"February 7, 2019","format":false,"excerpt":"Body, R., Carley, S.,\u00a0McDowell, G., Pemberton, P., Burrows, G., Cook, G., Lewis, P.S., Smith, A., Mackway-Jones, K. (2014) \u2018The Manchester Acute Coronary Syndromes (MACS) decision rule for suspected cardiac chest pain: derivation and external validation.\u2019 Heart 100 pp. 1462-1468.\u00a0 Objective:We aimed to derive and validate a clinical decision rule (CDR)\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2019\/01\/MACS-Paper-e1549807711724.png?fit=400%2C331&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":624,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=624","url_meta":{"origin":121,"position":4},"title":"P-Selectin in AMI","date":"February 7, 2019","format":false,"excerpt":"Body, R., Pemberton, P., Ali, F.,\u00a0McDowell, G., Carley, S., Smith, A. & Mackway-Jones, K. (2011) \u2018Low soluble P-selectin may facilitate early exclusion of acute myocardial infarction.\u2019\u00a0Clin Chem Acta412 pp. 614-618. Background:Suspected cardiac chest pain accounts for over 25% of medical admissions but, as only a minority have acute coronary syndromes,\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2019\/01\/P-Selectin-1-e1549807984127.png?fit=400%2C333&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":641,"url":"http:\/\/clinicalbiochemistry.net\/?page_id=641","url_meta":{"origin":121,"position":5},"title":"A FABP-ulous rule out strategy","date":"February 7, 2019","format":false,"excerpt":"Body, R.,\u00a0McDowell, G., Carley, S., Wibberley, C., Ferguson, J. & Mackway-Jones, K. (2011) \u2018A FABP-ulous rule out strategy? Heart fatty acid binding protein and troponin for rapid exclusion of acute myocardial infarction.\u2019\u00a0Resuscitation82 pp. 1041-1046.\u00a0 Objective:Many Emergency Departments (EDs) utilise \u2018triple marker\u2019 testing with CK-MB, myoglobin and troponin I (cTnI) to\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/clinicalbiochemistry.net\/wp-content\/uploads\/2019\/01\/Quanti-HFABP-e1549807872944.png?fit=400%2C341&resize=350%2C200","width":350,"height":200},"classes":[]}],"_links":{"self":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages\/121"}],"collection":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=121"}],"version-history":[{"count":5,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages\/121\/revisions"}],"predecessor-version":[{"id":875,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/pages\/121\/revisions\/875"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=\/wp\/v2\/media\/123"}],"wp:attachment":[{"href":"http:\/\/clinicalbiochemistry.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}